73439-19-7
73439-19-7 structure
- Name: COH-SR4
- Chemical Name: 1,3-Bis(3,5-dichlorophenyl)urea
- CAS Number: 73439-19-7
- Molecular Formula: C13H8Cl4N2O
- Molecular Weight: 350.027
- Create Date: 2020-01-12 00:58:15
- Modify Date: 2023-01-27 10:51:39
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COH-SR4 (Mitochondria uncoupler SR4) is a bonafide uncoupler that induces energetic stress on cells, consequently leading to AMPK activation and mTOR inhibition without any effects on ERK/MEK MAPK signaling; prevents cell proliferation and promoted cell death in many human cancers including leukemia, lung cancer, melanoma, and hepatocarcinoma in vitro and in animal models; exhibits a strong inhibitory effect on the survival of melanoma cells (B16-F0 cell line IC50=5 uM, Hs600T cell lineI C50=6 uM, and A2058 cell line IC50=11 uM), does not cause any significant cytotoxicity in normal human aortic vascular smooth muscle cells (HAVSMC); inhibits vemurafenib-resistant melanoma in vivo.
| Name | 1,3-Bis(3,5-dichlorophenyl)urea |
|---|---|
| Synonyms |
Urea, N,N'-bis(3,5-dichlorophenyl)-
1,3-Bis(3,5-dichlorophenyl)urea MFCD01566238 |
| Description | COH-SR4 (Mitochondria uncoupler SR4) is a bonafide uncoupler that induces energetic stress on cells, consequently leading to AMPK activation and mTOR inhibition without any effects on ERK/MEK MAPK signaling; prevents cell proliferation and promoted cell death in many human cancers including leukemia, lung cancer, melanoma, and hepatocarcinoma in vitro and in animal models; exhibits a strong inhibitory effect on the survival of melanoma cells (B16-F0 cell line IC50=5 uM, Hs600T cell lineI C50=6 uM, and A2058 cell line IC50=11 uM), does not cause any significant cytotoxicity in normal human aortic vascular smooth muscle cells (HAVSMC); inhibits vemurafenib-resistant melanoma in vivo. |
|---|---|
| References | References 1. Singhal SS, et al. Biochem Pharmacol. 2012 Dec 1;84(11):1419-27. 2. Figarola JL, et al. Oncotarget. 2018 Dec 11;9(97):36945-36965. 3. Singhal SS, et al. Biochem Pharmacol. 2013 Dec 15;86(12):1664-72. 4. Figarola JL, et al. PLoS One. 2013 Dec 20;8(12):e83801. View Related Products by Target Other Targets |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 363.2±42.0 °C at 760 mmHg |
| Melting Point | 298-300 °C |
| Molecular Formula | C13H8Cl4N2O |
| Molecular Weight | 350.027 |
| Flash Point | 173.5±27.9 °C |
| Exact Mass | 347.939087 |
| LogP | 7.01 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.706 |
| Hazard Codes | Xn |
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