855291-54-2
855291-54-2 structure
- Name: ABT-107
- Chemical Name: Abt-107 Free Base
- CAS Number: 855291-54-2
- Molecular Formula: C19H20N4O
- Molecular Weight: 320.388
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
- Create Date: 2020-01-11 13:09:09
- Modify Date: 2024-04-09 17:16:07
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ABT-107 is a potent and selective α7 nAChR agonist with Ki of 0.2-0.6 nM for rat or human cortex α7 nAChRs; displays >100-fold selective versus non-α7 nAChRs and other receptors; potently evokes human and rat α7 nAChR current responses in oocytes (EC50=50-90 nM) enhanced by A-867744; reduces spinal tau hyperphosphorylation in tau/amyloid precursor protein transgenic AD mice; improves cognition in monkey. Alzheimer Disease Phase 2 Discontinued
| Name | Abt-107 Free Base |
|---|---|
| Synonyms |
Abt-107 Free Base
5-[6-(1-Azabicyclo[2.2.2]oct-3-yloxy)-3-pyridazinyl]-1H-indole 1-Azabicyclo[2.2.2]octane, 3-[[6-(1H-indol-5-yl)-3-pyridazinyl]oxy]- |
| Description | ABT-107 is a potent and selective α7 nAChR agonist with Ki of 0.2-0.6 nM for rat or human cortex α7 nAChRs; displays >100-fold selective versus non-α7 nAChRs and other receptors; potently evokes human and rat α7 nAChR current responses in oocytes (EC50=50-90 nM) enhanced by A-867744; reduces spinal tau hyperphosphorylation in tau/amyloid precursor protein transgenic AD mice; improves cognition in monkey. Alzheimer Disease Phase 2 Discontinued |
|---|---|
| References | References 1. Malysz J, et al. J Pharmacol Exp Ther. 2010 Sep 1;334(3):863-74. 2. Bitner RS, et al. J Pharmacol Exp Ther. 2010 Sep 1;334(3):875-86. 3. Lee AM, et al. Behav Brain Res. 2014 Nov 1;274:168-75. View Related Products by Target nAChR Alzheimer Disease |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 598.0±50.0 °C at 760 mmHg |
| Molecular Formula | C19H20N4O |
| Molecular Weight | 320.388 |
| Flash Point | 315.4±30.1 °C |
| Exact Mass | 320.163696 |
| LogP | 2.18 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.699 |