862975-18-6

862975-18-6 structure

Name: MLS-0437605
Chemical Name: 4-Fluoro-N-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-1,3-benzothiazol-2-amine
CAS Number: 862975-18-6
Molecular Formula: C₁₆H₁₁FN₄O₂S
Molecular Weight: 342.348
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
Create Date: 2020-01-11 18:49:50
Modify Date: 2024-04-03 11:07:55
MLS-0437605 is a specific inhibitor of dual-specificity phosphatase 3 (DUSP3) with IC50 of 3.7 uM, 7-fold selectivity over USP22 and >4-fold selectivity over other 10 PTPs (HePTP, TCPTP, PTP1B, etc.); specifically inhibits collagen- and C-type lectin-like receptor 2-induced human platelet aggregation, thereby phenocopying the effect of DUSP3 deficiency in murine cells.

Name	4-Fluoro-N-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-1,3-benzothiazol-2-amine
Synonyms	2-Benzothiazolamine, 4-fluoro-N-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]- 4-Fluoro-N-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-1,3-benzothiazol-2-amine

Description	MLS-0437605 is a specific inhibitor of dual-specificity phosphatase 3 (DUSP3) with IC50 of 3.7 uM, 7-fold selectivity over USP22 and >4-fold selectivity over other 10 PTPs (HePTP, TCPTP, PTP1B, etc.); specifically inhibits collagen- and C-type lectin-like receptor 2-induced human platelet aggregation, thereby phenocopying the effect of DUSP3 deficiency in murine cells.
References	References 1. Musumeci L, et al. Circulation. 2015 Feb 17;131(7):656-68. View Related Products by Target Protein Phosphatase/PTP