880813-42-3
880813-42-3 structure
- Name: CMP-5
- Chemical Name: 1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-pyridinylmethyl)methanamine
- CAS Number: 880813-42-3
- Molecular Formula: C21H21N3
- Molecular Weight: 315.411
- Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
- Create Date: 2020-01-11 08:11:54
- Modify Date: 2024-01-11 19:04:14
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CMP-5 (PRMT5-IN-5)is a first-in-class, small-molecule PRMT5-specific inhibitor that blocks EBV-driven B-lymphocyte transformation and survival, without effect on normal B cells; displays no activity against other type I (PRMT1 and PRMT4) and type II (PRMT7) enzymes; inhibition of PRMT5 leads to lost recruitment of a PRMT5/p65/HDAC3-repressive complex on the miR96 promoter, restored miR96 expression, and PRMT5 downregulation.
| Name | 1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-pyridinylmethyl)methanamine |
|---|---|
| Synonyms |
9H-Carbazole-3-methanamine, 9-ethyl-N-(2-pyridinylmethyl)-
1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-pyridinylmethyl)methanamine |
| Description | CMP-5 (PRMT5-IN-5)is a first-in-class, small-molecule PRMT5-specific inhibitor that blocks EBV-driven B-lymphocyte transformation and survival, without effect on normal B cells; displays no activity against other type I (PRMT1 and PRMT4) and type II (PRMT7) enzymes; inhibition of PRMT5 leads to lost recruitment of a PRMT5/p65/HDAC3-repressive complex on the miR96 promoter, restored miR96 expression, and PRMT5 downregulation. |
|---|---|
| References | References 1. Alinari L, et al. Blood. 2015 Apr 16;125(16):2530-43. View Related Products by Target Histone Methyltransferase (HMTase) |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 505.1±48.0 °C at 760 mmHg |
| Molecular Formula | C21H21N3 |
| Molecular Weight | 315.411 |
| Flash Point | 259.3±29.6 °C |
| Exact Mass | 315.173553 |
| LogP | 4.23 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.637 |