942285-55-4

942285-55-4 structure

Name: P11
Chemical Name: (2S,6S)-6-(4-Methylphenyl)-1-[(4-methylphenyl)sulfonyl]-2-[4-(2-methyl-2-propanyl)phenyl]-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid
CAS Number: 942285-55-4
Molecular Formula: C₃₀H₃₃NO₄S
Molecular Weight: 503.652
Catalog: Research Areas Cancer
Create Date: 2020-01-20 19:08:55
Modify Date: 2024-01-09 19:04:25
PAFAH inhibitor P11 (P11) is a potent, selective platelet-activating factor acetylhydrolases PAFAH1b2 and PAFAH1b3 inhibitor with IC50 of 40 nM and 900 nM respectively; blocks PAFAH1b2- and PAFAH1b3-mediated hydrolysis of the substrate PAF to lyso-PAF with IC50 values of 36 nM and 880 nM; impairs tumor cell survival; in situ-active and can be used to investigate the cellular functions of PAFAH1b2/3.

Name	(2S,6S)-6-(4-Methylphenyl)-1-[(4-methylphenyl)sulfonyl]-2-[4-(2-methyl-2-propanyl)phenyl]-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid
Synonyms	(2S,6S)-6-(4-Methylphenyl)-1-[(4-methylphenyl)sulfonyl]-2-[4-(2-methyl-2-propanyl)phenyl]-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid 3-Pyridinecarboxylic acid, 2-[4-(1,1-dimethylethyl)phenyl]-1,2,5,6-tetrahydro-6-(4-methylphenyl)-1-[(4-methylphenyl)sulfonyl]-, (2S,6S)-

Description	PAFAH inhibitor P11 (P11) is a potent, selective platelet-activating factor acetylhydrolases PAFAH1b2 and PAFAH1b3 inhibitor with IC50 of 40 nM and 900 nM respectively; blocks PAFAH1b2- and PAFAH1b3-mediated hydrolysis of the substrate PAF to lyso-PAF with IC50 values of 36 nM and 880 nM; impairs tumor cell survival; in situ-active and can be used to investigate the cellular functions of PAFAH1b2/3.
References	References 1. Chang JW, et al. ACS Chem Biol. 2015 Apr 17;10(4):925-32. View Related Products by Target Other Targets