96748-86-6
96748-86-6 structure
- Name: deoxynyboquinone
- Chemical Name: deoxynyboquinone
- CAS Number: 96748-86-6
- Molecular Formula: C15H12N2O4
- Molecular Weight: 284.267
- Catalog: Research Areas Cancer
- Create Date: 2020-01-11 13:08:39
- Modify Date: 2024-01-12 09:03:21
-
Deoxynyboquinone (NSC 165572;DNQ) is a potent inducer of cancer cell death that induces death of cancer cells in culture with IC50 of 16-210 nM, a substrate for NAD(P)H:quinone oxidoreductase (NQO1); it's lethality relies on NQO1-dependent futile redox cycling that consumes oxygen and generates extensive reactive oxygen species (ROS).
| Name | deoxynyboquinone |
|---|---|
| Synonyms |
1,4,6-Trimethylpyrido[3,2-g]quinoline-2,5,8,10(1H,9H)-tetrone
Pyrido[3,2-g]quinoline-2,5,8,10(1H,9H)-tetrone, 1,4,6-trimethyl- deoxynyboquinone |
| Description | Deoxynyboquinone (NSC 165572;DNQ) is a potent inducer of cancer cell death that induces death of cancer cells in culture with IC50 of 16-210 nM, a substrate for NAD(P)H:quinone oxidoreductase (NQO1); it's lethality relies on NQO1-dependent futile redox cycling that consumes oxygen and generates extensive reactive oxygen species (ROS). |
|---|---|
| References | References 1. Bair JS, et al. J Am Chem Soc. 2010 Apr 21;132(15):5469-78. 2. Huang X, et al. Cancer Res. 2012 Jun 15;72(12):3038-47. 3. Lee HY, et al. ACS Chem Biol. 2017 May 19;12(5):1416-1424. View Related Products by Target Other Targets |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 591.2±50.0 °C at 760 mmHg |
| Molecular Formula | C15H12N2O4 |
| Molecular Weight | 284.267 |
| Flash Point | 311.4±30.1 °C |
| Exact Mass | 284.079712 |
| LogP | -0.41 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.659 |