1005776-20-4
1005776-20-4 structure
- Name: CLK inhibitor 2
- Chemical Name: CLK inhibitor 2
- CAS Number: 1005776-20-4
- Molecular Formula: C20H20N6O
- Molecular Weight: 360.421
- Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
- Create Date: 2020-01-11 18:35:49
- Modify Date: 2024-01-04 14:50:46
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A potent, selective inhibitor of cdc2-like kinase CLK1 and CLK2 with IC50 of 1.1 and 2.4 nM, respectively; moderately inhibits PI3Kα, and >100-fold selectivity over SRPK1/2/3; inhibits phospho-SRSF4 in MDA-MB-468 cells, induces alternative splicing of the S6K pre-mRNA at 1.1-3.3 uM, exhibits growth inhibitory activity with GI50 of 3.0 uM, through splicing alterations in genes involved in growth and survival.
| Name | CLK inhibitor 2 |
|---|
| Description | A potent, selective inhibitor of cdc2-like kinase CLK1 and CLK2 with IC50 of 1.1 and 2.4 nM, respectively; moderately inhibits PI3Kα, and >100-fold selectivity over SRPK1/2/3; inhibits phospho-SRSF4 in MDA-MB-468 cells, induces alternative splicing of the S6K pre-mRNA at 1.1-3.3 uM, exhibits growth inhibitory activity with GI50 of 3.0 uM, through splicing alterations in genes involved in growth and survival. |
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| References | References 1. Araki S, et al. PLoS One. 2015 Jan 12;10(1):e0116929. 2. Shi Y, et al. Bioorg Med Chem Lett. 2017 Feb 1;27(3):406-412. View Related Products by Target Cdc2-like Kinase (CLK) |
| Molecular Formula | C20H20N6O |
|---|---|
| Molecular Weight | 360.421 |