CLK inhibitor 2
Modify Date: 2025-08-24 19:59:30
CLK inhibitor 2 structure
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Common Name | CLK inhibitor 2 | ||
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| CAS Number | 1005776-20-4 | Molecular Weight | 360.421 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H20N6O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CLK inhibitor 2A potent, selective inhibitor of cdc2-like kinase CLK1 and CLK2 with IC50 of 1.1 and 2.4 nM, respectively; moderately inhibits PI3Kα, and >100-fold selectivity over SRPK1/2/3; inhibits phospho-SRSF4 in MDA-MB-468 cells, induces alternative splicing of the S6K pre-mRNA at 1.1-3.3 uM, exhibits growth inhibitory activity with GI50 of 3.0 uM, through splicing alterations in genes involved in growth and survival. |
| Name | CLK inhibitor 2 |
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| Description | A potent, selective inhibitor of cdc2-like kinase CLK1 and CLK2 with IC50 of 1.1 and 2.4 nM, respectively; moderately inhibits PI3Kα, and >100-fold selectivity over SRPK1/2/3; inhibits phospho-SRSF4 in MDA-MB-468 cells, induces alternative splicing of the S6K pre-mRNA at 1.1-3.3 uM, exhibits growth inhibitory activity with GI50 of 3.0 uM, through splicing alterations in genes involved in growth and survival. |
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| References | References 1. Araki S, et al. PLoS One. 2015 Jan 12;10(1):e0116929. 2. Shi Y, et al. Bioorg Med Chem Lett. 2017 Feb 1;27(3):406-412. View Related Products by Target Cdc2-like Kinase (CLK) |
| Molecular Formula | C20H20N6O |
|---|---|
| Molecular Weight | 360.421 |