1020814-70-3
1020814-70-3 structure
- Name: RO 5073012
- Chemical Name: RO 5073012
- CAS Number: 1020814-70-3
- Molecular Formula: C13H16ClN3
- Molecular Weight: 249.742
- Create Date: 2020-01-12 10:05:50
- Modify Date: 2024-03-05 15:36:11
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A potent, selective, orally active TAAR1 partial agonist with Ki of 6 nM, EC50 of 23 nM (hTAAR1), 140-fold selectivity over β2 adrenergic receptors; restores the psychostimulant effects of amphetamine on locomotion in Taar1 transgenic mice, exhibits good pharmacokinetic profile after oral administration in rodents and is active in a CNS behavioural models.
| Name | RO 5073012 |
|---|
| Description | A potent, selective, orally active TAAR1 partial agonist with Ki of 6 nM, EC50 of 23 nM (hTAAR1), 140-fold selectivity over β2 adrenergic receptors; restores the psychostimulant effects of amphetamine on locomotion in Taar1 transgenic mice, exhibits good pharmacokinetic profile after oral administration in rodents and is active in a CNS behavioural models. |
|---|---|
| References | References 1. Galley G, et al. Bioorg Med Chem Lett. 2012 Aug 15;22(16):5244-8. 2. Revel FG, et al. Neuropsychopharmacology. 2012 Nov;37(12):2580-92. View Related Products by Target Trace Amine-associated Receptor (TAAR) |
| Molecular Formula | C13H16ClN3 |
|---|---|
| Molecular Weight | 249.742 |