1287451-26-6
1287451-26-6 structure
- Name: ARN-5187
- Chemical Name: ARN-5187
- CAS Number: 1287451-26-6
- Molecular Formula: C24H32FN3O
- Molecular Weight: 397.538
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2020-01-20 16:25:56
- Modify Date: 2024-04-05 10:08:43
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A novel lysosomotropic REV-ERB ligand that has a dual inhibitory activity toward REV-ERB-mediated transcriptional regulation and autophagy; relieves REV-ERB-mediated transcriptional repression, significantly increases autophagy-associated protein p62 in treated cells; disrupts lysosomal function, blocks the autophagy process at the late stage, and reduces cancer cell viability; a novel dual autophagy/REV-ERB inhibitor more cytotoxic than chloroquine.
| Name | ARN-5187 |
|---|
| Description | A novel lysosomotropic REV-ERB ligand that has a dual inhibitory activity toward REV-ERB-mediated transcriptional regulation and autophagy; relieves REV-ERB-mediated transcriptional repression, significantly increases autophagy-associated protein p62 in treated cells; disrupts lysosomal function, blocks the autophagy process at the late stage, and reduces cancer cell viability; a novel dual autophagy/REV-ERB inhibitor more cytotoxic than chloroquine. |
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| References | References 1. De Mei C, et al. Oncogene. 2015 May 14;34(20):2597-608. View Related Products by Target Autophagy |
| Molecular Formula | C24H32FN3O |
|---|---|
| Molecular Weight | 397.538 |