164025-33-6
164025-33-6 structure
- Name: PWZ-029
- Chemical Name: PWZ-029
- CAS Number: 164025-33-6
- Molecular Formula: C14H14ClN3O2
- Molecular Weight: 291.735
- Create Date: 2020-01-11 15:34:49
- Modify Date: 2024-11-08 00:24:01
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PWZ-029 is a potent, subtype-selective partial inverse agonist of α5 GABAA receptors with Ki of 30 nM, demonstrates memory enhancing effects in vivo; successfully reverses the 0.3 mg/kg scopolamine-induced deficit in recognition memory at 2 mg/kg dose with no effect on anxiety or muscle tone.
| Name | PWZ-029 |
|---|
| Description | PWZ-029 is a potent, subtype-selective partial inverse agonist of α5 GABAA receptors with Ki of 30 nM, demonstrates memory enhancing effects in vivo; successfully reverses the 0.3 mg/kg scopolamine-induced deficit in recognition memory at 2 mg/kg dose with no effect on anxiety or muscle tone. |
|---|---|
| References | References 1. Savić MM, et al. Brain Res. 2008 May 7;1208:150-9. 2. Milić M, et al. Behav Brain Res. 2013 Mar 15;241:206-13. 3. Soto PL, et al. Neuropsychopharmacology. 2013 Oct;38(11):2315-25. 4. Timić Stamenić T, et al. J Psychopharmacol. 2015 Sep;29(9):1013-24. View Related Products by Target GABA Receptor |
| Molecular Formula | C14H14ClN3O2 |
|---|---|
| Molecular Weight | 291.735 |