1895876-81-9
1895876-81-9 structure
- Name: PI3K-IN-16
- Chemical Name: PI3K-IN-16
- CAS Number: 1895876-81-9
- Molecular Formula: C25H26FN3O5
- Molecular Weight: 467.497
- Create Date: 2020-01-12 13:31:22
- Modify Date: 2024-04-02 14:37:43
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PI3K-IN-16 is a potent and selective, orally bioavailable PI3Kβ and PI3Kδ inhibitor with cell IC50 of 12 nM (in PTEN null MDA-MB-468 cell) and 47 nM (in Jeko-1 B-cell), respectively; exhibits no significant activity on PI3Kα; shows profound pharmacodynamic modulation of AKT phosphorylation, excellent tumour growth inhibition in a mouse PTEN-deficient PC3 prostate tumour xenograft.
| Name | PI3K-IN-16 |
|---|
| Description | PI3K-IN-16 is a potent and selective, orally bioavailable PI3Kβ and PI3Kδ inhibitor with cell IC50 of 12 nM (in PTEN null MDA-MB-468 cell) and 47 nM (in Jeko-1 B-cell), respectively; exhibits no significant activity on PI3Kα; shows profound pharmacodynamic modulation of AKT phosphorylation, excellent tumour growth inhibition in a mouse PTEN-deficient PC3 prostate tumour xenograft. |
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| References | References 1. Barlaam B, et al. Bioorg Med Chem Lett. 2016 May 1;26(9):2318-23. View Related Products by Target PI3K |
| Molecular Formula | C25H26FN3O5 |
|---|---|
| Molecular Weight | 467.497 |