1918238-72-8
1918238-72-8 structure
- Name: JAK3i
- Chemical Name: JAK3i
- CAS Number: 1918238-72-8
- Molecular Formula: C18H15FN4O3
- Molecular Weight: 354.34
- Catalog: Signaling Pathways Epigenetics JAK
- Create Date: 2020-01-12 07:05:50
- Modify Date: 2025-09-08 23:00:12
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JAK3i is a selective, covalent JAK3 kinase inhibitor with IC50 of 0.43 nM, shows high selectivity (>3,000-fold) against the closely related kinase domains in JAK1, JAK2, or TYK2, displays 1,300-fold, 600-fold, and 50-fold over EGFR, ITK, and BTK respectively.
| Name | JAK3i |
|---|
| Description | JAK3i is a selective, covalent JAK3 kinase inhibitor with IC50 of 0.43 nM, shows high selectivity (>3,000-fold) against the closely related kinase domains in JAK1, JAK2, or TYK2, displays 1,300-fold, 600-fold, and 50-fold over EGFR, ITK, and BTK respectively. |
|---|---|
| References | References 1. Smith GA, et al. Nat Chem Biol. 2016 May;12(5):373-9. View Related Products by Target JAK |
| Molecular Formula | C18H15FN4O3 |
|---|---|
| Molecular Weight | 354.34 |