2082752-83-6
2082752-83-6 structure
- Name: ZGN-1061
- Chemical Name: ZGN-1061
- CAS Number: 2082752-83-6
- Molecular Formula: C26H42N2O6
- Molecular Weight: 478.63
- Catalog: Research Areas Metabolic Disease
- Create Date: 2020-01-20 16:03:56
- Modify Date: 2025-09-12 17:14:13
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ZGN-1061 (Aclimostat) is a novel potent, selective Methionine aminopeptidase 2 (MetAP2) inhibitor being investigated for treatment of diabetes and obesity; reduces body weight in diet-induced obese (DIO) insulin-resistant mice, also produced improvements in metabolic parameters, including plasma glucose and insulin, and, in HepG2 cells, initiated gene changes similar to beloranib; does not increase coagulation markers in dogs and ZGN-1061 had a greatly improved safety profile in rats relative to beloranib. Diabetes Phase 2 Clinical
| Name | ZGN-1061 |
|---|
| Description | ZGN-1061 (Aclimostat) is a novel potent, selective Methionine aminopeptidase 2 (MetAP2) inhibitor being investigated for treatment of diabetes and obesity; reduces body weight in diet-induced obese (DIO) insulin-resistant mice, also produced improvements in metabolic parameters, including plasma glucose and insulin, and, in HepG2 cells, initiated gene changes similar to beloranib; does not increase coagulation markers in dogs and ZGN-1061 had a greatly improved safety profile in rats relative to beloranib. Diabetes Phase 2 Clinical |
|---|---|
| References | References 1. Burkey BF, et al. J Pharmacol Exp Ther. 2018 Feb 28. pii: jpet.117.246272. View Related Products by Target Aminopeptidase Diabetes |
| Molecular Formula | C26H42N2O6 |
|---|---|
| Molecular Weight | 478.63 |