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2115700-64-4

2115700-64-4 structure
2115700-64-4 structure
  • Name: C5-benzyl SAHA
  • Chemical Name: C5-benzyl SAHA
  • CAS Number: 2115700-64-4
  • Molecular Formula: C21H26N2O3
  • Molecular Weight: 354.45
  • Create Date: 2020-01-11 16:44:49
  • Modify Date: 2024-09-16 13:34:46
  • C5-benzyl SAHA is a C5-modified SAHA analog that displays dual selectivity to HDAC6 (IC50=0.27 uM) and HDAC8 (IC50=0.38 uM) over HDAC 1, 2, and 3 (IC50=2.9-5.8 uM); dose dependently and selectively increases in levels of acetyl-α-tubulin in U937 leukemia cells.

Name C5-benzyl SAHA
Description C5-benzyl SAHA is a C5-modified SAHA analog that displays dual selectivity to HDAC6 (IC50=0.27 uM) and HDAC8 (IC50=0.38 uM) over HDAC 1, 2, and 3 (IC50=2.9-5.8 uM); dose dependently and selectively increases in levels of acetyl-α-tubulin in U937 leukemia cells.
References References 1. Negmeldin AT, et al. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3254-3258. View Related Products by Target HDAC
Molecular Formula C21H26N2O3
Molecular Weight 354.45