2115700-64-4
2115700-64-4 structure
- Name: C5-benzyl SAHA
- Chemical Name: C5-benzyl SAHA
- CAS Number: 2115700-64-4
- Molecular Formula: C21H26N2O3
- Molecular Weight: 354.45
- Create Date: 2020-01-11 16:44:49
- Modify Date: 2024-09-16 13:34:46
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C5-benzyl SAHA is a C5-modified SAHA analog that displays dual selectivity to HDAC6 (IC50=0.27 uM) and HDAC8 (IC50=0.38 uM) over HDAC 1, 2, and 3 (IC50=2.9-5.8 uM); dose dependently and selectively increases in levels of acetyl-α-tubulin in U937 leukemia cells.
| Name | C5-benzyl SAHA |
|---|
| Description | C5-benzyl SAHA is a C5-modified SAHA analog that displays dual selectivity to HDAC6 (IC50=0.27 uM) and HDAC8 (IC50=0.38 uM) over HDAC 1, 2, and 3 (IC50=2.9-5.8 uM); dose dependently and selectively increases in levels of acetyl-α-tubulin in U937 leukemia cells. |
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| References | References 1. Negmeldin AT, et al. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3254-3258. View Related Products by Target HDAC |
| Molecular Formula | C21H26N2O3 |
|---|---|
| Molecular Weight | 354.45 |