Name | DI-591 |
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Description | DI-591 (DI591) is a potent, selective, cell-permeable inhibitor of the DCN1-UBC12 interaction with Ki of 10-12 nM for human DCN1 and DCN2; displays no affinity against DCN3/4/5 (Ki>10 uM); selectively inhibits neddylation of cullin 3 but has no or minimal effect on neddylation of other cullin family members; accumulates NRF2 protein and its transcriptional activation in cells. |
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References | References 1. Zhou H, et al. Nat Commun. 2017 Oct 27;8(1):1150. View Related Products by Target Ubiquitin-conjugating Enzyme (E2) |
Molecular Formula | C31H47N5O4S |
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Molecular Weight | 585.808 |