301177-36-6
301177-36-6 structure
- Name: RH01386
- Chemical Name: RH01386
- CAS Number: 301177-36-6
- Molecular Formula: C18H15F3N4O3S
- Molecular Weight: 424.398
- Catalog: Research Areas Metabolic Disease
- Create Date: 2020-01-16 18:21:26
- Modify Date: 2024-04-03 07:11:24
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RH01386 is a small molecule that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death; increases the survival of human primary β cells and rodent β cell lines subjected to ER stressors including palmitate; also restores ER stress-impaired glucose-stimulated insulin secretion responses.
| Name | RH01386 |
|---|
| Description | RH01386 is a small molecule that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death; increases the survival of human primary β cells and rodent β cell lines subjected to ER stressors including palmitate; also restores ER stress-impaired glucose-stimulated insulin secretion responses. |
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| Related Catalog | |
| Target |
ER stress-induced β cell dysfunction[1] |
| In Vitro | RH01386 (270 nM-70 μM; 72 hours) is confirmed to increase ATP levels in βTC6 cells treated with (tunicamycin) Tm, exhibits a EC50 value of 1.894 μM[1]. RH01386 (270 nM-70 μM; 72 hours) dose-dependently inhibits (tunicamycin) Tm-induced cell death, and inhibits the activity of caspase-3, a downstream effector of the apoptotic pathway in βTC6 cells[1]. Cell Viability Assay[1] Cell Line: βTC6 cells Concentration: 270 nM-70 μM Incubation Time: 72 hours Result: Inhibited ER stress-induced death of βTC6 cells in a dose-dependent manner. Apoptosis Analysis[1] Cell Line: βTC6 cells Concentration: 270 nM-70 μM Incubation Time: 72 hours Result: Protected βTC6 cells from Tm-induced cell death. |
| References |
| Molecular Formula | C18H15F3N4O3S |
|---|---|
| Molecular Weight | 424.398 |