790241-43-9
790241-43-9 structure
- Name: DB818
- Chemical Name: DB818
- CAS Number: 790241-43-9
- Molecular Formula: C19H16N6S
- Molecular Weight: 360.439
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2020-01-11 16:18:50
- Modify Date: 2024-09-08 16:11:42
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DB818 (DB-818, DB 818) is a small molecule inhibitor of HOXA9/DNA interaction through binding as minor groove DNA ligand on the HOXA9 cognate sequence; directly bind to HOXA9-cognate sequence with Kd value of 4.6 nM (HBS sequence); alters HOXA9-mediated transcription, cell survival and cell cycle inHOXA9-mediated HOXA9-expressing murine MigA9 cell line.
| Name | DB818 |
|---|
| Description | DB818 (DB-818, DB 818) is a small molecule inhibitor of HOXA9/DNA interaction through binding as minor groove DNA ligand on the HOXA9 cognate sequence; directly bind to HOXA9-cognate sequence with Kd value of 4.6 nM (HBS sequence); alters HOXA9-mediated transcription, cell survival and cell cycle inHOXA9-mediated HOXA9-expressing murine MigA9 cell line. |
|---|---|
| References | References 1. Depauw S, et al. J Med Chem. 2019 Jan 15. doi: 10.1021/acs.jmedchem.8b01448. View Related Products by Target Other Targets |
| Molecular Formula | C19H16N6S |
|---|---|
| Molecular Weight | 360.439 |