1005307-86-7
1005307-86-7 structure
- Name: PR5-LL-CM01
- Chemical Name: PR5-LL-CM01
- CAS Number: 1005307-86-7
- Molecular Formula: C23H27N7
- Molecular Weight: 401.518
- Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
- Create Date: 2020-01-20 14:43:55
- Modify Date: 2024-02-02 18:59:33
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PR5-LL-CM01 is a novel selective, small-molecule inhibitor of PRMT5 methyltransferase with IC50 of 7.5 uM; displays >10-fold selectivity over PRMT3, and no inhibitory activity over PRMT1/4/6/8; exhibits cell viability inhibition with IC50 of 2-4 uM in PDAC cells, IC50 of 10-11 uM in CRC cells, more potent than EPZ015666; significantly inhibits NF-κB activation in PDAC and CRC cells, and shows dramatic anti-tumor efficacy in vivo.
| Name | PR5-LL-CM01 |
|---|
| Description | PR5-LL-CM01 is a novel selective, small-molecule inhibitor of PRMT5 methyltransferase with IC50 of 7.5 uM; displays >10-fold selectivity over PRMT3, and no inhibitory activity over PRMT1/4/6/8; exhibits cell viability inhibition with IC50 of 2-4 uM in PDAC cells, IC50 of 10-11 uM in CRC cells, more potent than EPZ015666; significantly inhibits NF-κB activation in PDAC and CRC cells, and shows dramatic anti-tumor efficacy in vivo. |
|---|---|
| References | References 1. Prabhu L, et al. Oncotarget. 2017 Jun 20;8(25):39963-39977. View Related Products by Target Histone Methyltransferase (HMTase) |
| Molecular Formula | C23H27N7 |
|---|---|
| Molecular Weight | 401.518 |