1062592-30-6
1062592-30-6 structure
- Name: NS13001
- Chemical Name: NS13001
- CAS Number: 1062592-30-6
- Molecular Formula: C16H14ClN7
- Molecular Weight: 339.787
- Create Date: 2020-01-20 18:04:56
- Modify Date: 2023-01-14 07:51:30
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A potent, selective, allosteric and orally acitve positive modulator of small-conductance calcium-activated K+ channel KCa2.2 and KCa2.3 with EC50 of 1.6 and 0.14 uM, respectively; shows no activating effect on hSK1 or hIK channels (EC50>10 uM), and exerts less off-target effects; alleviates behavioral and neuropathological phenotypes of aging spinocerebellar ataxia type 2 (SCA2) transgenic mice.
| Name | NS13001 |
|---|
| Description | A potent, selective, allosteric and orally acitve positive modulator of small-conductance calcium-activated K+ channel KCa2.2 and KCa2.3 with EC50 of 1.6 and 0.14 uM, respectively; shows no activating effect on hSK1 or hIK channels (EC50>10 uM), and exerts less off-target effects; alleviates behavioral and neuropathological phenotypes of aging spinocerebellar ataxia type 2 (SCA2) transgenic mice. |
|---|---|
| References | References 1. Kasumu AW, et al. Chem Biol. 2012 Oct 26;19(10):1340-53. 2. Coleman N, et al. Mol Pharmacol. 2014 Sep;86(3):342-57. View Related Products by Target Potassium Channel |
| Molecular Formula | C16H14ClN7 |
|---|---|
| Molecular Weight | 339.787 |