1113025-86-7
1113025-86-7 structure
- Name: LB-205
- Chemical Name: LB-205
- CAS Number: 1113025-86-7
- Molecular Formula: C18H21N3O2S
- Molecular Weight: 343.445
- Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
- Create Date: 2020-01-19 22:14:56
- Modify Date: 2024-08-30 10:47:57
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A Zn2+-dependent pan-inhibitor of class I and class II HDACs with a long half-life (12h) in vivo; significantly enhances the migration of astrocytes and accelerates wound repair more effectively than SAHA and VPA; up-regulates the expression of NGF, phospho-TrkA, p-AKT, NF-κB, and Bcl-2, while down-regulates the expression of p75 NTR, phospho-JNK, and Bax.
| Name | LB-205 |
|---|
| Description | A Zn2+-dependent pan-inhibitor of class I and class II HDACs with a long half-life (12h) in vivo; significantly enhances the migration of astrocytes and accelerates wound repair more effectively than SAHA and VPA; up-regulates the expression of NGF, phospho-TrkA, p-AKT, NF-κB, and Bcl-2, while down-regulates the expression of p75 NTR, phospho-JNK, and Bax. |
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| References | References 1. Lu J, et al. Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21200-5. 2. Lu J, et al. Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10747-52. View Related Products by Target HDAC |
| Molecular Formula | C18H21N3O2S |
|---|---|
| Molecular Weight | 343.445 |