1159724-42-1
1159724-42-1 structure
- Name: BI-1950
- Chemical Name: BI-1950
- CAS Number: 1159724-42-1
- Molecular Formula: C32H26Cl2FN7O3
- Molecular Weight: 646.504
- Catalog: Signaling Pathways Cytoskeleton Integrin
- Create Date: 2020-01-20 09:38:56
- Modify Date: 2024-01-27 11:21:32
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BI-1950 is a potent, selective LFA-1 antagonist that inhibits the binding of LFA-1 to ICAM-1 with Kd value of 9 nM; displays >1,000 fold selectivity against the most closely related b2-integrin Mac-1 and b1-integrin function; inhibits the production of IL-2 in human PBMC and whole blood with IC50 value of 3 nM and 120 nM, respectively; exhibits an attractive DMPK profile, BI-1950 is a excellent molecule for testing pharmacological hypotheses in vitro and in vivo.
| Name | BI-1950 |
|---|
| Description | BI-1950 is a potent, selective LFA-1 antagonist that inhibits the binding of LFA-1 to ICAM-1 with Kd value of 9 nM; displays >1,000 fold selectivity against the most closely related b2-integrin Mac-1 and b1-integrin function; inhibits the production of IL-2 in human PBMC and whole blood with IC50 value of 3 nM and 120 nM, respectively; exhibits an attractive DMPK profile, BI-1950 is a excellent molecule for testing pharmacological hypotheses in vitro and in vivo. |
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| References | References View Related Products by Target Other Targets |
| Molecular Formula | C32H26Cl2FN7O3 |
|---|---|
| Molecular Weight | 646.504 |