BI-1950
Modify Date: 2025-08-27 20:19:42
BI-1950 structure
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Common Name | BI-1950 | ||
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| CAS Number | 1159724-42-1 | Molecular Weight | 646.504 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C32H26Cl2FN7O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BI-1950BI-1950 is a potent, selective LFA-1 antagonist that inhibits the binding of LFA-1 to ICAM-1 with Kd value of 9 nM; displays >1,000 fold selectivity against the most closely related b2-integrin Mac-1 and b1-integrin function; inhibits the production of IL-2 in human PBMC and whole blood with IC50 value of 3 nM and 120 nM, respectively; exhibits an attractive DMPK profile, BI-1950 is a excellent molecule for testing pharmacological hypotheses in vitro and in vivo. |
| Name | BI-1950 |
|---|
| Description | BI-1950 is a potent, selective LFA-1 antagonist that inhibits the binding of LFA-1 to ICAM-1 with Kd value of 9 nM; displays >1,000 fold selectivity against the most closely related b2-integrin Mac-1 and b1-integrin function; inhibits the production of IL-2 in human PBMC and whole blood with IC50 value of 3 nM and 120 nM, respectively; exhibits an attractive DMPK profile, BI-1950 is a excellent molecule for testing pharmacological hypotheses in vitro and in vivo. |
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| References | References View Related Products by Target Other Targets |
| Molecular Formula | C32H26Cl2FN7O3 |
|---|---|
| Molecular Weight | 646.504 |
| InChIKey | JZTTUZXIQIRVAB-FZEVHQGJSA-N |
| SMILES | CC(NC(=O)c1cnc2n1C(C)(Cc1ccc(C#N)cc1)C(=O)N2c1cc(Cl)c(F)c(Cl)c1)C(=O)NC1(c2ccccn2)CC1 |