1176326-78-5
1176326-78-5 structure
- Name: DSP-1053
- Chemical Name: DSP-1053
- CAS Number: 1176326-78-5
- Molecular Formula: C32H38BrNO7S
- Molecular Weight: 660.62
- Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
- Create Date: 2020-01-20 09:26:55
- Modify Date: 2024-04-08 19:33:32
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DSP-1053 is a novel potent serotonin reuptake (SERT) inhibitor with 5-HT1A partial agonistic activity that binds to human serotonin transporter and 5-HT1A receptor with Ki of 1.02 and 5.05 nM, respectively; inhibits serotonin transporter with IC50 of 2.74 nM and shows an intrinsic activity for 5-HT1A receptors of 70.0%; dose-dependently increases extracellular 5-HT levels in rat microdialysis at 3-10 mg/kg, demonstrates antidepressant-like effect in vivo. Depression Phase 1 Discontinued
| Name | DSP-1053 |
|---|
| Description | DSP-1053 is a novel potent serotonin reuptake (SERT) inhibitor with 5-HT1A partial agonistic activity that binds to human serotonin transporter and 5-HT1A receptor with Ki of 1.02 and 5.05 nM, respectively; inhibits serotonin transporter with IC50 of 2.74 nM and shows an intrinsic activity for 5-HT1A receptors of 70.0%; dose-dependently increases extracellular 5-HT levels in rat microdialysis at 3-10 mg/kg, demonstrates antidepressant-like effect in vivo. Depression Phase 1 Discontinued |
|---|---|
| References | References 1. Yoshinaga H, et al. Bioorg Med Chem. 2018 May 1;26(8):1614-1627. 2. Kato T, et al. Pharmacol Res Perspect. 2015 Jun;3(3):e00142. View Related Products by Target 5-HT Receptor Depression |
| Molecular Formula | C32H38BrNO7S |
|---|---|
| Molecular Weight | 660.62 |