117739-40-9
117739-40-9 structure
- Name: XX-650-23
- Chemical Name: XX-650-23
- CAS Number: 117739-40-9
- Molecular Formula: C18H12N2O2
- Molecular Weight: 288.306
- Create Date: 2020-01-12 10:50:50
- Modify Date: 2024-04-07 13:25:29
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XX-650-23 is a small molecule inhibitor of CREB, blocks CREB/CBP interaction (IC50=3.2 uM) and disrupts CREB-driven gene expression; suppresses AML cell lines growth with IC50 of 0.87-2.3 uM, specifically disrupts CREB-driven transcription, induces apoptosis and cell-cycle arrest; significantly increases survival of cell line- and patient-derived xenograft mice with no toxicity to normal hematopoietic cells or animals.
| Name | XX-650-23 |
|---|
| Description | XX-650-23 is a small molecule inhibitor of CREB, blocks CREB/CBP interaction (IC50=3.2 uM) and disrupts CREB-driven gene expression; suppresses AML cell lines growth with IC50 of 0.87-2.3 uM, specifically disrupts CREB-driven transcription, induces apoptosis and cell-cycle arrest; significantly increases survival of cell line- and patient-derived xenograft mice with no toxicity to normal hematopoietic cells or animals. |
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| References | References 1. Mitton B, et al. Leukemia. 2016 Dec;30(12):2302-2311. 2. François S, et al. J Virol. 2016 Sep 12;90(19):8686-97. View Related Products by Target CREB/CBP |
| Molecular Formula | C18H12N2O2 |
|---|---|
| Molecular Weight | 288.306 |