117739-40-9

117739-40-9 structure

Name: XX-650-23
Chemical Name: XX-650-23
CAS Number: 117739-40-9
Molecular Formula: C₁₈H₁₂N₂O₂
Molecular Weight: 288.306
Create Date: 2020-01-12 10:50:50
Modify Date: 2024-04-07 13:25:29
XX-650-23 is a small molecule inhibitor of CREB, blocks CREB/CBP interaction (IC50=3.2 uM) and disrupts CREB-driven gene expression; suppresses AML cell lines growth with IC50 of 0.87-2.3 uM, specifically disrupts CREB-driven transcription, induces apoptosis and cell-cycle arrest; significantly increases survival of cell line- and patient-derived xenograft mice with no toxicity to normal hematopoietic cells or animals.

Name	XX-650-23

Description	XX-650-23 is a small molecule inhibitor of CREB, blocks CREB/CBP interaction (IC50=3.2 uM) and disrupts CREB-driven gene expression; suppresses AML cell lines growth with IC50 of 0.87-2.3 uM, specifically disrupts CREB-driven transcription, induces apoptosis and cell-cycle arrest; significantly increases survival of cell line- and patient-derived xenograft mice with no toxicity to normal hematopoietic cells or animals.
References	References 1. Mitton B, et al. Leukemia. 2016 Dec;30(12):2302-2311. 2. François S, et al. J Virol. 2016 Sep 12;90(19):8686-97. View Related Products by Target CREB/CBP

Molecular Formula	C₁₈H₁₂N₂O₂
Molecular Weight	288.306