1185908-92-2
1185908-92-2 structure
- Name: EC-70124
- Chemical Name: EC-70124
- CAS Number: 1185908-92-2
- Molecular Formula: C26H19N3O5
- Molecular Weight: 453.454
- Create Date: 2020-01-20 01:58:55
- Modify Date: 2024-04-03 16:36:25
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EC-70124 is a multikinase inhibitor with potent activity against several AML related kinases including FLT3, JAK, SYK or Pim kinases (Kd<10 nM); inhibits 7 out of 9 FLT3 mutants, also acts as a dual STAT3/NF-kB inhibitor, reverting both tumorigenic and stem cell properties in prostate cancer; inhibits AML cell proliferation and induces cell cycle arrest and apoptosis; in vivo oral treatment causes complete regression in AML tumor xenograft models, and ex vivo inhibits proliferation in AML patient blasts at biochemically relevant doses.
| Name | EC-70124 |
|---|
| Description | EC-70124 is a multikinase inhibitor with potent activity against several AML related kinases including FLT3, JAK, SYK or Pim kinases (Kd<10 nM); inhibits 7 out of 9 FLT3 mutants, also acts as a dual STAT3/NF-kB inhibitor, reverting both tumorigenic and stem cell properties in prostate cancer; inhibits AML cell proliferation and induces cell cycle arrest and apoptosis; in vivo oral treatment causes complete regression in AML tumor xenograft models, and ex vivo inhibits proliferation in AML patient blasts at biochemically relevant doses. |
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| References | References 1. Civenni G, et al. Mol Cancer Ther. 2016 May;15(5):806-18. 2. Cuenca-López MD, et al. Oncotarget. 2015 Sep 29;6(29):27923-37. 3. Puente-Moncada N, et al. 4. Sánchez C, et al. Chem Commun (Camb). 2009 Jul 21;(27):4118-20. View Related Products by Target FLT3 |
| Molecular Formula | C26H19N3O5 |
|---|---|
| Molecular Weight | 453.454 |