1190948-58-3
1190948-58-3 structure
- Name: Diptoindonesin G
- Chemical Name: Diptoindonesin G
- CAS Number: 1190948-58-3
- Molecular Formula: C21H12O6
- Molecular Weight: 360.321
- Create Date: 2020-01-11 15:00:50
- Modify Date: 2024-01-28 19:48:29
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A natural compound, novel chemical probe reciprocally stabilizes ERβ and destabilizes ERα in breast cancer cells; targets CHIP ubiquitin E3 ligase to modulate ER protein stability, enhances the transcription and anti-proliferative activities of ERβ, while attenuating the transcription and proliferative effects of ERα; the first small molecule that can restore the balance of ERα and ERβ.
| Name | Diptoindonesin G |
|---|
| Description | A natural compound, novel chemical probe reciprocally stabilizes ERβ and destabilizes ERα in breast cancer cells; targets CHIP ubiquitin E3 ligase to modulate ER protein stability, enhances the transcription and anti-proliferative activities of ERβ, while attenuating the transcription and proliferative effects of ERα; the first small molecule that can restore the balance of ERα and ERβ. |
|---|---|
| References | References 1. Zhao Z, et al. Chem Biol. 2015 Dec 17;22(12):1608-21. 2. Juliawaty LD, et al. Nat Prod Commun. 2009 Jul; 4(7):947-50. 3. Gao J, et al. Cell Death Dis. 2017 May 4;8(5):e2765. View Related Products by Target Estrogen Receptor/ERR |
| Molecular Formula | C21H12O6 |
|---|---|
| Molecular Weight | 360.321 |