1208248-23-0
1208248-23-0 structure
- Name: MET inhibitor Compound 1
- Chemical Name: MET inhibitor Compound 1
- CAS Number: 1208248-23-0
- Molecular Formula: C21H17F2N9O
- Molecular Weight: 449.426
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK c-Met/HGFR
- Create Date: 2020-01-12 04:40:49
- Modify Date: 2024-02-07 00:56:23
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A novel potent, selective orally bioavailable MET tyrosine kinase inhibitor with IC50 of <1 nM and 12 nM for unphosphorylated and phosphorylaed MET, respectively; demonstrates potent, broad spectrum activity against MET mutants (V1110I, H1112Y, L1195V, Y1235D, D1228H and M1250T) with IC50 of <1 nM-57 nM, and Y1230 mutants with moderate potency (IC50=25-280 nM); displays >50-fold selectivity in a panel of 130 kinases with exception of Fms and TrkA/B/C; inhibits MET-dependent tumor cell growth in vivo through decreasing phosphorylaed MET.
| Name | MET inhibitor Compound 1 |
|---|
| Description | A novel potent, selective orally bioavailable MET tyrosine kinase inhibitor with IC50 of <1 nM and 12 nM for unphosphorylated and phosphorylaed MET, respectively; demonstrates potent, broad spectrum activity against MET mutants (V1110I, H1112Y, L1195V, Y1235D, D1228H and M1250T) with IC50 of <1 nM-57 nM, and Y1230 mutants with moderate potency (IC50=25-280 nM); displays >50-fold selectivity in a panel of 130 kinases with exception of Fms and TrkA/B/C; inhibits MET-dependent tumor cell growth in vivo through decreasing phosphorylaed MET. |
|---|---|
| References | References 1. Farrell PJ, et al. Mol Cancer Ther. 2017 Jul;16(7):1269-1278. View Related Products by Target c-Met (HGFR) |
| Molecular Formula | C21H17F2N9O |
|---|---|
| Molecular Weight | 449.426 |