1219962-49-8
1219962-49-8 structure
- Name: AT791
- Chemical Name: AT791
- CAS Number: 1219962-49-8
- Molecular Formula: C23H31N3O3
- Molecular Weight: 397.519
- Catalog: Signaling Pathways Immunology/Inflammation Toll-like Receptor (TLR)
- Create Date: 2020-01-11 19:19:49
- Modify Date: 2024-01-11 12:56:58
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AT791 is a novel orally available, small molecule inhibitor of TLR7 and TLR9 with IC50 of 3.33 uM and 0.04 uM respectively, inhibits DNA-TLR9 interaction in vitro; shows weak activity against TLR4 (IC50>10 uM); potently inhibits IL-6 production induced by CpG2216 and suppresses both IL-6 and α-interferon production induced by CpG oligo.
| Name | AT791 |
|---|
| Description | AT791 is a novel orally available, small molecule inhibitor of TLR7 and TLR9 with IC50 of 3.33 uM and 0.04 uM respectively, inhibits DNA-TLR9 interaction in vitro; shows weak activity against TLR4 (IC50>10 uM); potently inhibits IL-6 production induced by CpG2216 and suppresses both IL-6 and α-interferon production induced by CpG oligo. |
|---|---|
| References | References 1. Lamphier M, et al. Mol Pharmacol. 2014 Mar;85(3):429-40. View Related Products by Target Toll-like Receptor (TLR) |
| Molecular Formula | C23H31N3O3 |
|---|---|
| Molecular Weight | 397.519 |