AT791

Modify Date: 2024-01-11 12:56:58

AT791 Structure
AT791 structure
 Common Name AT791
CAS Number 1219962-49-8 Molecular Weight 397.519
Density N/A Boiling Point N/A
Molecular Formula C23H31N3O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of AT791


AT791 is a novel orally available, small molecule inhibitor of TLR7 and TLR9 with IC50 of 3.33 uM and 0.04 uM respectively, inhibits DNA-TLR9 interaction in vitro; shows weak activity against TLR4 (IC50>10 uM); potently inhibits IL-6 production induced by CpG2216 and suppresses both IL-6 and α-interferon production induced by CpG oligo.

 Names

Name AT791

 AT791 Biological Activity

Description AT791 is a novel orally available, small molecule inhibitor of TLR7 and TLR9 with IC50 of 3.33 uM and 0.04 uM respectively, inhibits DNA-TLR9 interaction in vitro; shows weak activity against TLR4 (IC50>10 uM); potently inhibits IL-6 production induced by CpG2216 and suppresses both IL-6 and α-interferon production induced by CpG oligo.
References References 1. Lamphier M, et al. Mol Pharmacol. 2014 Mar;85(3):429-40. View Related Products by Target Toll-like Receptor (TLR)

 Chemical & Physical Properties

Molecular Formula C23H31N3O3
Molecular Weight 397.519
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Chemsrc provides AT791(CAS#:1219962-49-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of AT791 are included as well.>> amp version: AT791

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