1245792-67-9
1245792-67-9 structure
- Name: BCI-215
- Chemical Name: BCI-215
- CAS Number: 1245792-67-9
- Molecular Formula: C22H22BrNO
- Molecular Weight: 396.328
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
- Create Date: 2020-01-20 17:53:55
- Modify Date: 2024-01-08 20:07:19
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BCI-215 (BCI215) is a potent, tumor cell-selective dual specificity MAPK phosphatase (DUSP-MKP) inhibitor; restores defective MAPK activity caused by overexpression of DUSP1 and DUSP6 in mammalian cells; inhibits cell motility, causes apoptosis but not primary necrosis, and sensitizes cells to lymphokine-activated killer cell activity in MDA-MB-231 human breast cancer cells; induces rapid and sustained phosphorylation of ERK, p38 and JNK, also hyperactivates MKK4/SEK1; causes selective cancer cell cytotoxicity in part through non-redox-mediated activation of MAPK signaling.
| Name | BCI-215 |
|---|
| Description | BCI-215 (BCI215) is a potent, tumor cell-selective dual specificity MAPK phosphatase (DUSP-MKP) inhibitor; restores defective MAPK activity caused by overexpression of DUSP1 and DUSP6 in mammalian cells; inhibits cell motility, causes apoptosis but not primary necrosis, and sensitizes cells to lymphokine-activated killer cell activity in MDA-MB-231 human breast cancer cells; induces rapid and sustained phosphorylation of ERK, p38 and JNK, also hyperactivates MKK4/SEK1; causes selective cancer cell cytotoxicity in part through non-redox-mediated activation of MAPK signaling. |
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| References | References 1. Kaltenmeier CT, et al. J Pharmacol Exp Ther. 2017 Apr;361(1):39-50. View Related Products by Target Protein Phosphatase/PTP |
| Molecular Formula | C22H22BrNO |
|---|---|
| Molecular Weight | 396.328 |