1318166-37-8
1318166-37-8 structure
- Name: (-)-CXL017
- Chemical Name: (-)-CXL017
- CAS Number: 1318166-37-8
- Molecular Formula: C24H27NO7
- Molecular Weight: 441.48
- Create Date: 2020-01-11 16:55:49
- Modify Date: 2024-10-05 21:42:46
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(-)-CXL017 is a small molecule that has selective cytotoxicity toward MDR cancer cell lines in vitro, through inhibition of the sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) with IC50 of 13.5 uM; selectively suppresses the growth of tumors derived from the MDR cancer cell line, HL60/MX2, in vivo; significantly downregulates Mcl-1 and Bax and up-regulates Noxa, Bim, Bcl-XL, SERCA2, and SERCA3 proteins, along with a reduction in endoplasmic reticulum (ER) calcium content in HL60/MX2 cells; elicits its cytotoxic effect, in part, through inhibition of the SERCA.
| Name | (-)-CXL017 |
|---|
| Description | (-)-CXL017 is a small molecule that has selective cytotoxicity toward MDR cancer cell lines in vitro, through inhibition of the sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) with IC50 of 13.5 uM; selectively suppresses the growth of tumors derived from the MDR cancer cell line, HL60/MX2, in vivo; significantly downregulates Mcl-1 and Bax and up-regulates Noxa, Bim, Bcl-XL, SERCA2, and SERCA3 proteins, along with a reduction in endoplasmic reticulum (ER) calcium content in HL60/MX2 cells; elicits its cytotoxic effect, in part, through inhibition of the SERCA. |
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| References | References 1. Bleeker NP, et al. Mol Pharm. 2013 Nov 4;10(11):4358-66. View Related Products by Target Other Targets |
| Molecular Formula | C24H27NO7 |
|---|---|
| Molecular Weight | 441.48 |