1351056-65-9
1351056-65-9 structure
- Name: OSU-2S
- Chemical Name: OSU-2S
- CAS Number: 1351056-65-9
- Molecular Formula: C21H37NO2
- Molecular Weight: 335.532
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2020-01-20 18:28:55
- Modify Date: 2024-01-14 18:20:37
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A non-immunosuppressive FTY720 analogue, PKCδ activator with higher antiproliferative potency with IC50 of 2.4, 2.4, and 3.5 uM in Huh7, Hep3B, and PLC5 cells, respectively; exhibited higher in vitro antiproliferative efficacy relative to FTY720 against HCC cells without cytotoxicity in normal hepatocytes, although devoid of S1P1 receptor activity; induces caspase-dependent apoptosis through ROS-dependent PKCδ activation in HCC tumor cells.
| Name | OSU-2S |
|---|
| Description | A non-immunosuppressive FTY720 analogue, PKCδ activator with higher antiproliferative potency with IC50 of 2.4, 2.4, and 3.5 uM in Huh7, Hep3B, and PLC5 cells, respectively; exhibited higher in vitro antiproliferative efficacy relative to FTY720 against HCC cells without cytotoxicity in normal hepatocytes, although devoid of S1P1 receptor activity; induces caspase-dependent apoptosis through ROS-dependent PKCδ activation in HCC tumor cells. |
|---|---|
| References | References 1. Omar HA, et al. Hepatology. 2011 Jun;53(6):1943-58. 2. Mani R, et al. Leukemia. 2015 Feb;29(2):346-55. 3. Mani R, et al. Exp Hematol. 2015 Sep;43(9):770-4.e2. 4. Omar HA, et al. Front Pharmacol. 2016 Nov 30;7:463. eCollection 2016. View Related Products by Target PKC |
| Molecular Formula | C21H37NO2 |
|---|---|
| Molecular Weight | 335.532 |