1352609-28-9
1352609-28-9 structure
- Name: EW-7195
- Chemical Name: EW-7195
- CAS Number: 1352609-28-9
- Molecular Formula: C23H18N8
- Molecular Weight: 406.453
- Catalog: Signaling Pathways MAPK/ERK Pathway p38 MAPK
- Create Date: 2020-01-11 18:45:50
- Modify Date: 2024-01-11 12:05:00
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A novel potent and selective TGF-βRI (ALK5) inhibitor with IC50 of 4.83 nM, dispalys >300-fold selectivity over p38α; decreases phosphorylated Smad2 levels and the nuclear translocation of Smad2 increased by TGF-β1, inhibits TGF-β1-induced epithelial-to-mesenchymal transition (EMT) and wound healing of NMuMG cells; inhibits metastasis to lung from breast tumours in xenografted mice.
| Name | EW-7195 |
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| Description | A novel potent and selective TGF-βRI (ALK5) inhibitor with IC50 of 4.83 nM, dispalys >300-fold selectivity over p38α; decreases phosphorylated Smad2 levels and the nuclear translocation of Smad2 increased by TGF-β1, inhibits TGF-β1-induced epithelial-to-mesenchymal transition (EMT) and wound healing of NMuMG cells; inhibits metastasis to lung from breast tumours in xenografted mice. |
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| References | References 1. Park CY, et al. Eur J Cancer. 2011 Nov;47(17):2642-53. View Related Products by Target TGF beta Receptor (TGFBR) |
| Molecular Formula | C23H18N8 |
|---|---|
| Molecular Weight | 406.453 |