1360562-98-6
1360562-98-6 structure
- Name: XZH-5
- Chemical Name: XZH-5
- CAS Number: 1360562-98-6
- Molecular Formula: C22H25F6N5O4
- Molecular Weight: 537.463
- Catalog: Signaling Pathways JAK/STAT Signaling STAT
- Create Date: 2020-01-20 08:41:57
- Modify Date: 2024-01-06 10:53:18
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XZH-5 is a small moelcule that inhibits constitutive and interleukin-6-induced STAT3 phosphorylation, inhibits STAT3 DNA binding ability and downregulation of STAT3 downstream genes; inhibits downregulation of STAT3 downstream genes, such as Bcl-2, Bcl-xL, Cyclin D1 and Survivin, demonstrates blockade of STAT3 phosphorylation in human rhabdomyosarcoma cells with apoptosis and suppresses colony-forming ability and cell migration; blocks IL-6-induced STAT3 phosphorylation and nuclear translocation but not the stimulation of STAT1 phosphorylation by IFN-γ.
| Name | XZH-5 |
|---|
| Description | XZH-5 is a small moelcule that inhibits constitutive and interleukin-6-induced STAT3 phosphorylation, inhibits STAT3 DNA binding ability and downregulation of STAT3 downstream genes; inhibits downregulation of STAT3 downstream genes, such as Bcl-2, Bcl-xL, Cyclin D1 and Survivin, demonstrates blockade of STAT3 phosphorylation in human rhabdomyosarcoma cells with apoptosis and suppresses colony-forming ability and cell migration; blocks IL-6-induced STAT3 phosphorylation and nuclear translocation but not the stimulation of STAT1 phosphorylation by IFN-γ. |
|---|---|
| References | References 1. Liu Y, et al. Apoptosis. 2011 May;16(5):502-10. 2. Liu A, et al. Cancer Sci. 2011 Jul;102(7):1381-7. 3. Liu A, PLoS One. 2012;7(10):e46624. 4. Daka P, et al. Bioorg Med Chem. 2015 Mar 15;23(6):1348-55. View Related Products by Target STAT |
| Molecular Formula | C22H25F6N5O4 |
|---|---|
| Molecular Weight | 537.463 |