XZH-5
Modify Date: 2024-01-06 10:53:18
XZH-5 structure
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Common Name | XZH-5 | ||
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| CAS Number | 1360562-98-6 | Molecular Weight | 537.463 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H25F6N5O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of XZH-5XZH-5 is a small moelcule that inhibits constitutive and interleukin-6-induced STAT3 phosphorylation, inhibits STAT3 DNA binding ability and downregulation of STAT3 downstream genes; inhibits downregulation of STAT3 downstream genes, such as Bcl-2, Bcl-xL, Cyclin D1 and Survivin, demonstrates blockade of STAT3 phosphorylation in human rhabdomyosarcoma cells with apoptosis and suppresses colony-forming ability and cell migration; blocks IL-6-induced STAT3 phosphorylation and nuclear translocation but not the stimulation of STAT1 phosphorylation by IFN-γ. |
| Name | XZH-5 |
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| Description | XZH-5 is a small moelcule that inhibits constitutive and interleukin-6-induced STAT3 phosphorylation, inhibits STAT3 DNA binding ability and downregulation of STAT3 downstream genes; inhibits downregulation of STAT3 downstream genes, such as Bcl-2, Bcl-xL, Cyclin D1 and Survivin, demonstrates blockade of STAT3 phosphorylation in human rhabdomyosarcoma cells with apoptosis and suppresses colony-forming ability and cell migration; blocks IL-6-induced STAT3 phosphorylation and nuclear translocation but not the stimulation of STAT1 phosphorylation by IFN-γ. |
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| References | References 1. Liu Y, et al. Apoptosis. 2011 May;16(5):502-10. 2. Liu A, et al. Cancer Sci. 2011 Jul;102(7):1381-7. 3. Liu A, PLoS One. 2012;7(10):e46624. 4. Daka P, et al. Bioorg Med Chem. 2015 Mar 15;23(6):1348-55. View Related Products by Target STAT |
| Molecular Formula | C22H25F6N5O4 |
|---|---|
| Molecular Weight | 537.463 |