1364692-88-5

1364692-88-5 structure

Name: AMPK activator SC4
Chemical Name: AMPK activator SC4
CAS Number: 1364692-88-5
Molecular Formula: C₂₆H₁₈ClN₃O₄
Molecular Weight: 471.897
Create Date: 2020-01-12 09:33:50
Modify Date: 2024-01-11 12:46:01
AMPK activator SC4 is a potent, specific activator of α2β2-AMPK complexes with EC50 of 17.2 and 82.1 nM for α2β2γ1 and α2β2γ3, the predominant AMPK isoform complexes in human skeletal muscle; does not significantly stimulate activities of the α1-equivalent complexes α1β2γ1 and α1β2γ3 at 5 uM; Deletion β-subunit carbohydrate binding module (CBM) abolished SC4 activation; preferentially activates α2 complexes and stimulates skeletal muscle glucose uptake.

Name	AMPK activator SC4

Description	AMPK activator SC4 is a potent, specific activator of α2β2-AMPK complexes with EC50 of 17.2 and 82.1 nM for α2β2γ1 and α2β2γ3, the predominant AMPK isoform complexes in human skeletal muscle; does not significantly stimulate activities of the α1-equivalent complexes α1β2γ1 and α1β2γ3 at 5 uM; Deletion β-subunit carbohydrate binding module (CBM) abolished SC4 activation; preferentially activates α2 complexes and stimulates skeletal muscle glucose uptake.
References	References 1. Ngoei KRW, et al. Cell Chem Biol. 2018 Jun 21;25(6):728-737.e9. View Related Products by Target AMPK

Molecular Formula	C₂₆H₁₈ClN₃O₄
Molecular Weight	471.897