1386455-51-1
1386455-51-1 structure
- Name: Factor D inhibitor 6
- Chemical Name: Factor D inhibitor 6
- CAS Number: 1386455-51-1
- Molecular Formula: C23H22ClFN6O3
- Molecular Weight: 484.916
- Catalog: Signaling Pathways Immunology/Inflammation Complement System
- Create Date: 2020-01-12 11:17:49
- Modify Date: 2023-01-20 01:41:46
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Factor D inhibitor 6 is a potent and selective, orally bioavailable inhibitor of Factor D with IC50 of 30 nM; is highly selective for human FD, showing no inhibition of factor B; efficiently block alternative pathway activation and prevent both C3 deposition onto, and lysis of, PNH erythrocytes; inhibits lipopolysaccharide-induced AP activation in FD-humanized mice.
| Name | Factor D inhibitor 6 |
|---|
| Description | Factor D inhibitor 6 is a potent and selective, orally bioavailable inhibitor of Factor D with IC50 of 30 nM; is highly selective for human FD, showing no inhibition of factor B; efficiently block alternative pathway activation and prevent both C3 deposition onto, and lysis of, PNH erythrocytes; inhibits lipopolysaccharide-induced AP activation in FD-humanized mice. |
|---|---|
| References | References 1. Maibaum J, et al. Nat Chem Biol. 2016 Dec;12(12):1105-1110. View Related Products by Target Complement System |
| Molecular Formula | C23H22ClFN6O3 |
|---|---|
| Molecular Weight | 484.916 |