1392816-46-4
1392816-46-4 structure
- Name: SI-113
- Chemical Name: SI-113
- CAS Number: 1392816-46-4
- Molecular Formula: C23H24N6O
- Molecular Weight: 400.486
- Catalog: Signaling Pathways Metabolic Enzyme/Protease SGK
- Create Date: 2020-01-11 18:04:49
- Modify Date: 2024-01-24 13:36:00
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SI-113(SI113;SI 113) is a potent, specific inhibitor of the SGK1 kinase activity, induces autophagy, apoptosis and ER stress in cancer cells; blocks insulin-dependent phosphorylation of the Sgk1 substrate Mdm2, and induces necrosis and apoptosis in RKO cells; potentiates the effects of paclitaxel on cell viability; active in vivo.
| Name | SI-113 |
|---|
| Description | SI-113(SI113;SI 113) is a potent, specific inhibitor of the SGK1 kinase activity, induces autophagy, apoptosis and ER stress in cancer cells; blocks insulin-dependent phosphorylation of the Sgk1 substrate Mdm2, and induces necrosis and apoptosis in RKO cells; potentiates the effects of paclitaxel on cell viability; active in vivo. |
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| References | References 1. D'Antona L, et al. Cell Physiol Biochem. 2015;35(5):2006-18. 2. Talarico C, et al. Oncotarget. 2015 Nov 10;6(35):37511-25. 3. Talarico C, et al. Oncotarget. 2016 Mar 29;7(13):15868-84. 4. Radi M, et al. J Med Chem. 2011 Apr 28;54(8):2610-26. View Related Products by Target SGK |
| Molecular Formula | C23H24N6O |
|---|---|
| Molecular Weight | 400.486 |