1422620-34-5
1422620-34-5 structure
- Name: T-3775440
- Chemical Name: T-3775440
- CAS Number: 1422620-34-5
- Molecular Formula: C18H22N4O
- Molecular Weight: 310.401
- Create Date: 2020-01-19 14:45:32
- Modify Date: 2024-01-08 17:01:57
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T-3775440 is a novel potent, selecitve, irreversible LSD1 inhibitor with IC50 of 2.1 nM; displays high selectivity for LSD1 relative to other monoamine oxidases (e.g., MAO-A and MAO-B); disrupts the interaction between LSD1 and growth factor-independent 1B (GFI1B) in leukemia cell lines, exhibites significant antitumor efficacy in AEL and AMKL xenograft models.
| Name | T-3775440 |
|---|
| Description | T-3775440 is a novel potent, selecitve, irreversible LSD1 inhibitor with IC50 of 2.1 nM; displays high selectivity for LSD1 relative to other monoamine oxidases (e.g., MAO-A and MAO-B); disrupts the interaction between LSD1 and growth factor-independent 1B (GFI1B) in leukemia cell lines, exhibites significant antitumor efficacy in AEL and AMKL xenograft models. |
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| References | References 1. Takagi S, et al. Cancer Res. 2017 Jun 30. pii: canres.3502.2016. 2. Ishikawa Y, et al. Mol Cancer Ther. 2017 Feb;16(2):273-284. View Related Products by Target Histone Demethylase |
| Molecular Formula | C18H22N4O |
|---|---|
| Molecular Weight | 310.401 |