1423067-48-4
1423067-48-4 structure
- Name: (Rac)-BI 703704
- Chemical Name: BI 703704
- CAS Number: 1423067-48-4
- Molecular Formula: C32H37N3O4S
- Molecular Weight: 559.725
- Catalog: Signaling Pathways GPCR/G Protein Guanylate Cyclase
- Create Date: 2020-01-12 12:03:50
- Modify Date: 2025-08-23 10:57:13
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A novel potent soluble guanylate cyclase (sGC) activator; reduces progression of renal damage in the ZSF1 rat, shows the potential as an effective therapy for diabetic nephropathy.
| Name | BI 703704 |
|---|
| Description | A novel potent soluble guanylate cyclase (sGC) activator; reduces progression of renal damage in the ZSF1 rat, shows the potential as an effective therapy for diabetic nephropathy. |
|---|---|
| Related Catalog | |
| In Vivo | (Rac)-BI 703704 (0.3-10 mg/kg; food intake; daily for 15 weeks) inhibits the progression of diabetic nephropathy in the ZSF1 rat[1]. Animal Model: 12-13 weeks male ZSF1 obese rats[1] Dosage: 0.3, 1, 3, or 10 mg/kg Administration: Food intake; daily for 15 weeks Result: Dose-dependent increased in renal cGMP levels; Dosedependent decreased in urinary protein excretion (UPE); Accompanied by a significant reduction in the incidence of glomerulosclerosis and interstitial lesions. |
| References |
| Molecular Formula | C32H37N3O4S |
|---|---|
| Molecular Weight | 559.725 |