1428327-35-8
1428327-35-8 structure
- Name: JNJ-42253432
- Chemical Name: JNJ-42253432
- CAS Number: 1428327-35-8
- Molecular Formula: C28H38N4O
- Molecular Weight: 446.639
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel P2X Receptor
- Create Date: 2020-01-11 17:11:50
- Modify Date: 2024-02-25 15:36:30
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A potent, selective, CNS-penetrant P2X7 antagonist with pKi of 9.1 and 7.9 for rat and huamn P2X7 channel, respectively; does not block calcium flux via human P2X1, P2X2, P2X3, P2X2/P2X3, and P2X4 at 10 uM; attenuates both ATP- and Bz-ATP-induced currents from hP2X7-1321N1 cells with similar potencies (pEC50=7.0), blocks the release of IL-1β induced by Bz-ATP in freely moving rat brain, also increases serotonin levels; attenuates amphetamine-induced hyperactivity in vivo.
| Name | JNJ-42253432 |
|---|
| Description | A potent, selective, CNS-penetrant P2X7 antagonist with pKi of 9.1 and 7.9 for rat and huamn P2X7 channel, respectively; does not block calcium flux via human P2X1, P2X2, P2X3, P2X2/P2X3, and P2X4 at 10 uM; attenuates both ATP- and Bz-ATP-induced currents from hP2X7-1321N1 cells with similar potencies (pEC50=7.0), blocks the release of IL-1β induced by Bz-ATP in freely moving rat brain, also increases serotonin levels; attenuates amphetamine-induced hyperactivity in vivo. |
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| References | References 1. Lord B, et al. J Pharmacol Exp Ther. 2014 Dec;351(3):628-41. 2. Amhaoul H, et al. Neuropharmacology. 2016 Jun;105:175-185. View Related Products by Target P2X Receptor |
| Molecular Formula | C28H38N4O |
|---|---|
| Molecular Weight | 446.639 |