1430798-22-3
1430798-22-3 structure
- Name: Isobutyl-deoxynyboquinone
- Chemical Name: Isobutyl-deoxynyboquinone
- CAS Number: 1430798-22-3
- Molecular Formula: C18H18N2O4
- Molecular Weight: 326.352
- Catalog: Research Areas Cancer
- Create Date: 2020-01-11 19:25:50
- Modify Date: 2025-08-23 17:57:03
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Isobutyl-deoxynyboquinone (IB-DNQ) is a selective substrate for NAD(P)H:quinone oxidoreductase (NQO1), produces ROS, and induces cytotoxicity in cancer cells in an NQO1-dependent manner; has improved solubility and biocompatibility in comparison with DNQ; a superior drug candidate for evaluating anticancer activities and tolerability in vivo.
| Name | Isobutyl-deoxynyboquinone |
|---|
| Description | Isobutyl-deoxynyboquinone (IB-DNQ) is a selective substrate for NAD(P)H:quinone oxidoreductase (NQO1), produces ROS, and induces cytotoxicity in cancer cells in an NQO1-dependent manner; has improved solubility and biocompatibility in comparison with DNQ; a superior drug candidate for evaluating anticancer activities and tolerability in vivo. |
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| References | References 1. Parkinson EI, et al. Acc Chem Res. 2015 Oct 20;48(10):2715-23. 2. Lundberg AP, et al. Invest New Drugs. 2017 Apr;35(2):134-144. 3. Parkinson EI, et al. ACS Chem Biol. 2013 Oct 18;8(10):2173-83. View Related Products by Target Other Targets |
| Molecular Formula | C18H18N2O4 |
|---|---|
| Molecular Weight | 326.352 |