Isobutyl-deoxynyboquinone

Modify Date: 2024-01-10 13:41:55

Isobutyl-deoxynyboquinone Structure
Isobutyl-deoxynyboquinone structure
Common Name Isobutyl-deoxynyboquinone
CAS Number 1430798-22-3 Molecular Weight 326.352
Density N/A Boiling Point N/A
Molecular Formula C18H18N2O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Isobutyl-deoxynyboquinone


Isobutyl-deoxynyboquinone (IB-DNQ) is a selective substrate for NAD(P)H:quinone oxidoreductase (NQO1), produces ROS, and induces cytotoxicity in cancer cells in an NQO1-dependent manner; has improved solubility and biocompatibility in comparison with DNQ; a superior drug candidate for evaluating anticancer activities and tolerability in vivo.

 Names

Name Isobutyl-deoxynyboquinone

 Isobutyl-deoxynyboquinone Biological Activity

Description Isobutyl-deoxynyboquinone (IB-DNQ) is a selective substrate for NAD(P)H:quinone oxidoreductase (NQO1), produces ROS, and induces cytotoxicity in cancer cells in an NQO1-dependent manner; has improved solubility and biocompatibility in comparison with DNQ; a superior drug candidate for evaluating anticancer activities and tolerability in vivo.
References References 1. Parkinson EI, et al. Acc Chem Res. 2015 Oct 20;48(10):2715-23. 2. Lundberg AP, et al. Invest New Drugs. 2017 Apr;35(2):134-144. 3. Parkinson EI, et al. ACS Chem Biol. 2013 Oct 18;8(10):2173-83. View Related Products by Target Other Targets

 Chemical & Physical Properties

Molecular Formula C18H18N2O4
Molecular Weight 326.352