1449764-45-7
1449764-45-7 structure
- Name: HJC 0726
- Chemical Name: HJC 0726
- CAS Number: 1449764-45-7
- Molecular Formula: C16H14Cl2N4O2
- Molecular Weight: 365.214
- Create Date: 2020-01-19 17:35:53
- Modify Date: 2024-03-03 18:53:29
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HJC 0726 is a potent Exchange proteins directly activated by cAMP (EPAC) inhibitor, inhibits cAMP-mediated EPAC2 GEF activity with IC50 of 1.0 uM; also inhibits EPAC1-mediated Rap1-GDP exchange activity; does not alter cAMP-induced type I and II PKA holoenzymes activation at 25 uM; inhibits GEF activity of the full-length EPAC1 in the presence of 20 µM cAMP with IC50 of 2.4 uM.
| Name | HJC 0726 |
|---|
| Description | HJC 0726 is a potent Exchange proteins directly activated by cAMP (EPAC) inhibitor, inhibits cAMP-mediated EPAC2 GEF activity with IC50 of 1.0 uM; also inhibits EPAC1-mediated Rap1-GDP exchange activity; does not alter cAMP-induced type I and II PKA holoenzymes activation at 25 uM; inhibits GEF activity of the full-length EPAC1 in the presence of 20 µM cAMP with IC50 of 2.4 uM. |
|---|---|
| References | References 1. Chen H, et al. J Med Chem. 2014 May 8;57(9):3651-65. 2. Chen H, et al. Bioorg Med Chem Lett. 2012 Jun 15;22(12):4038-43. 3. Juhász T, et al. Cell Signal. 2014 Mar;26(3):468-82. 4. Zhu Y, et al. Sci Rep. 2015 Mar 20;5:9344. View Related Products by Target Other Targets |
| Molecular Formula | C16H14Cl2N4O2 |
|---|---|
| Molecular Weight | 365.214 |