1562375-46-5
1562375-46-5 structure
- Name: SM-1295
- Chemical Name: SM-1295
- CAS Number: 1562375-46-5
- Molecular Formula: C29H36BrN5O4
- Molecular Weight: 598.542
- Catalog: Signaling Pathways Apoptosis IAP
- Create Date: 2020-01-12 11:26:50
- Modify Date: 2024-03-06 12:01:35
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SM-1295 is a potent, selective cIAP1 and cIAP2 inhibitor with Ki of <10 nM, displays >900-fold for cIAP1 over XIAP; potently inhibits cell growth in the MDA-MB-231 and SK-OV-3 cancer cell lines and induces apoptosis at low nanomolar concentrations; efficiently induces degradation of cIAP1 protein in cancer cells, as well as cleavage of PARP, caspase-8, and caspase-3; induces cell death in a TNFα-dependent manner in both MDA-MB-231 and SK-OV-3 cancer cell lines.
| Name | SM-1295 |
|---|
| Description | SM-1295 is a potent, selective cIAP1 and cIAP2 inhibitor with Ki of <10 nM, displays >900-fold for cIAP1 over XIAP; potently inhibits cell growth in the MDA-MB-231 and SK-OV-3 cancer cell lines and induces apoptosis at low nanomolar concentrations; efficiently induces degradation of cIAP1 protein in cancer cells, as well as cleavage of PARP, caspase-8, and caspase-3; induces cell death in a TNFα-dependent manner in both MDA-MB-231 and SK-OV-3 cancer cell lines. |
|---|---|
| References | References 1. Sun H, et al. ACS Chem Biol. 2014 Apr 18;9(4):994-1002. View Related Products by Target IAP |
| Molecular Formula | C29H36BrN5O4 |
|---|---|
| Molecular Weight | 598.542 |