1584631-89-9
1584631-89-9 structure
- Name: BMS-871
- Chemical Name: BMS-871
- CAS Number: 1584631-89-9
- Molecular Formula: C29H27F3N4O3
- Molecular Weight: 536.555
- Create Date: 2020-01-14 10:48:04
- Modify Date: 2024-08-13 12:49:18
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BMS-871 is a potent, orally active pan-Notch inhibitor with IC50 of 4/1/4/3 nM for Notch1/2/3/4, respectively; inhibits TALL-1 tumor cell proliferation with IC50 of 4 nM, displays robust in vivo efficacy in Notch-dependent leukemia and triple negative breast cancer xenografts.
| Name | BMS-871 |
|---|
| Description | BMS-871 is a potent, orally active pan-Notch inhibitor with IC50 of 4/1/4/3 nM for Notch1/2/3/4, respectively; inhibits TALL-1 tumor cell proliferation with IC50 of 4 nM, displays robust in vivo efficacy in Notch-dependent leukemia and triple negative breast cancer xenografts. |
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| References | References 1. Shan W, et al. Bioorg Med Chem Lett. 2015 May 1;25(9):1905-9. View Related Products by Target Notch |
| Molecular Formula | C29H27F3N4O3 |
|---|---|
| Molecular Weight | 536.555 |