1627962-21-3
1627962-21-3 structure
- Name: VS-II-173
- Chemical Name: VS-II-173
- CAS Number: 1627962-21-3
- Molecular Formula: C14H8N4O2
- Molecular Weight: 264.244
- Create Date: 2020-01-11 18:59:50
- Modify Date: 2024-01-11 23:45:04
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VS-II-173 is a highly potent Pim1 and Pim3 inhibitor with IC50 of 70 and 20 nM respectively, and a potent and selective inducer of AML cell death (IC50=5.5 uM, Molm-13 cell); acts synergistically with the anthracycline daunorubicin, and additively with a number of other anti-cancer drugs; attenuates phosphorylation of Pim kinase substrates, shows towards cell lines harboring the FLT3-ITD mutation (Molm-13, FLT3-ITD heterozygous and MV4-11 FLT3-ITD homozygous) with EC50 of 2-3 uM; also induces cell death also in AML patient blasts, including blast carrying high-risk FLT3-ITD mutation.
| Name | VS-II-173 |
|---|
| Description | VS-II-173 is a highly potent Pim1 and Pim3 inhibitor with IC50 of 70 and 20 nM respectively, and a potent and selective inducer of AML cell death (IC50=5.5 uM, Molm-13 cell); acts synergistically with the anthracycline daunorubicin, and additively with a number of other anti-cancer drugs; attenuates phosphorylation of Pim kinase substrates, shows towards cell lines harboring the FLT3-ITD mutation (Molm-13, FLT3-ITD heterozygous and MV4-11 FLT3-ITD homozygous) with EC50 of 2-3 uM; also induces cell death also in AML patient blasts, including blast carrying high-risk FLT3-ITD mutation. |
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| References | References 1. Suchaud V, et al. Bioorg Med Chem. 2014 Sep 1;22(17):4704-10. 2. Bjørnstad R, et al. Mol Cancer Ther. 2019 Jan 24. pii: molcanther.1234.2017. doi: 10.1158/1535-7163.MCT-17-1234. View Related Products by Target Pim |
| Molecular Formula | C14H8N4O2 |
|---|---|
| Molecular Weight | 264.244 |