1654775-71-9
1654775-71-9 structure
- Name: 4-Br-BnIm
- Chemical Name: 4-Br-BnIm
- CAS Number: 1654775-71-9
- Molecular Formula: C20H18BrClN2O4
- Molecular Weight: 465.728
- Catalog: Research Areas Metabolic Disease
- Create Date: 2020-01-19 20:45:56
- Modify Date: 2026-03-07 18:21:12
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A potent, subtype-selective Grp94 inhibitor with Kd of 0.96 uM, 13-fold selectivity over Hsp90α; facilitates mutant myocilin degradation and rescues phenotypes in a transgenic mouse model of hereditary primary open-angle glaucoma.
| Name | 4-Br-BnIm |
|---|
| Description | A potent, subtype-selective Grp94 inhibitor with Kd of 0.96 uM, 13-fold selectivity over Hsp90α; facilitates mutant myocilin degradation and rescues phenotypes in a transgenic mouse model of hereditary primary open-angle glaucoma. |
|---|---|
| References | References 1. Stothert AR, et al. Sci Rep. 2017 Dec 20;7(1):17951. 2. Crowley VM, et al. J Med Chem. 2016 Apr 14;59(7):3471-88. View Related Products by Target Heat Shock Protein (HSP) |
| Molecular Formula | C20H18BrClN2O4 |
|---|---|
| Molecular Weight | 465.728 |