1681021-52-2
1681021-52-2 structure
- Name: pan-PIM inhibitor 17
- Chemical Name: pan-PIM inhibitor 17
- CAS Number: 1681021-52-2
- Molecular Formula: C19H23ClN4O2
- Molecular Weight: 374.869
- Create Date: 2020-01-19 21:43:56
- Modify Date: 2024-02-04 17:01:51
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pan-PIM inhibitor 17 is a potent, selective, orally available inhibitor of Pim kinase with IC50 of 0.8, 5.1 and 1.8 nM for Pim1, 2 and 3, respectively; disaplays broad selectivity in an internal panel of 192 kinases, only eight kinases were inhibited above 50% at 1 uM; demonstrates cellular biomarker pS6 inhibition with EC50 of 27 nM, shows tumor growth inhibition in a KG1 tumor-bearing mouse model.
| Name | pan-PIM inhibitor 17 |
|---|
| Description | pan-PIM inhibitor 17 is a potent, selective, orally available inhibitor of Pim kinase with IC50 of 0.8, 5.1 and 1.8 nM for Pim1, 2 and 3, respectively; disaplays broad selectivity in an internal panel of 192 kinases, only eight kinases were inhibited above 50% at 1 uM; demonstrates cellular biomarker pS6 inhibition with EC50 of 27 nM, shows tumor growth inhibition in a KG1 tumor-bearing mouse model. |
|---|---|
| References | References 1. Barberis C, et al. Bioorg Med Chem Lett. 2018 Dec 10. pii: S0960-894X(18)30949-1. 2. Barberis C, et al. Bioorg Med Chem Lett. 2017 Oct 15;27(20):4735-4740. 3. Guo Z, et al. Blood. 2014 Sep 11;124(11):1777-89. View Related Products by Target Pim |
| Molecular Formula | C19H23ClN4O2 |
|---|---|
| Molecular Weight | 374.869 |